Syntheses of chlorogenin 6alpha-O-acyl-3-O-beta-chacotriosides and their antitumor activities

Yichun Zhang; Yingxia Li; Tiantian Guo; Huashi Guan; Jiwei Shi; Qiang Yu; Biao Yu

doi:10.1016/j.carres.2005.03.019

Syntheses of chlorogenin 6alpha-O-acyl-3-O-beta-chacotriosides and their antitumor activities

Carbohydr Res. 2005 Jun 13;340(8):1453-9. doi: 10.1016/j.carres.2005.03.019.

Authors

Yichun Zhang¹, Yingxia Li, Tiantian Guo, Huashi Guan, Jiwei Shi, Qiang Yu, Biao Yu

Affiliation

¹ Key Laboratory of Marine Drugs, Ministry of Education, Marine Drug and Food Institute, Ocean University of China, Qingdao.

PMID: 15882851
DOI: 10.1016/j.carres.2005.03.019

Abstract

Chlorogenin 3-O-beta-chacotrioside (1) and its 6alpha-O-acyl derivatives (2-6) were concisely synthesized. Introduction of a hydroxyl or acyloxy group onto the C-6 of the steroidal aglycone of dioscin decreased significantly the cytotoxicity of the parent saponin (dioscin).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
HeLa Cells
Humans
Inhibitory Concentration 50
Molecular Sequence Data
Molecular Structure
Saponins / chemical synthesis*
Saponins / chemistry
Saponins / pharmacology*

Substances

Antineoplastic Agents
Saponins