Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression

Radiother Oncol. 2005 Apr;75(1):70-3. doi: 10.1016/j.radonc.2004.12.013. Epub 2005 Mar 16.

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1 x 8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (> or =12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dose Fractionation, Radiation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Palliative Care
  • Radiation Injuries*
  • Spinal Cord Compression / etiology*
  • Spinal Cord Compression / radiotherapy*
  • Spinal Cord Neoplasms / complications
  • Spinal Cord Neoplasms / radiotherapy*
  • Spinal Cord Neoplasms / secondary*
  • Treatment Outcome