Restoration of connexin 43 by Bowman-Birk protease inhibitor in M5076 bearing mice

Oncol Rep. 2005 Jun;13(6):1247-50.

Abstract

The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0.493) were negatively correlated with the doses of BBI. In contrast, the relative density of Cx43 was positively correlated with the doses of BBI (p<0.05, r(2)=0.351). Therefore, it suggests that the anti-carcinogenic effects of BBI induced negative growth control caused by the expression of Cx43 genes in mice with M5076 ovarian sarcoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Connexin 43 / metabolism*
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Proliferating Cell Nuclear Antigen / metabolism
  • Sarcoma, Experimental / drug therapy*
  • Sarcoma, Experimental / metabolism
  • Sarcoma, Experimental / pathology
  • Trypsin Inhibitor, Bowman-Birk Soybean / therapeutic use*
  • Trypsin Inhibitors / therapeutic use*
  • Tumor Cells, Cultured

Substances

  • Connexin 43
  • Proliferating Cell Nuclear Antigen
  • Trypsin Inhibitor, Bowman-Birk Soybean
  • Trypsin Inhibitors