Abstract
To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Anaphase-Promoting Complex-Cyclosome
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Animals
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Cdc20 Proteins
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Cell Cycle Proteins / antagonists & inhibitors*
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Cell Cycle Proteins / genetics
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Humans
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Mitosis / genetics
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Mitosis / physiology*
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Molecular Sequence Data
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Phosphorylation
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Protein Kinases / metabolism*
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Protein Serine-Threonine Kinases / metabolism
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Saccharomyces cerevisiae Proteins / antagonists & inhibitors
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Saccharomyces cerevisiae Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism
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Sequence Homology, Amino Acid
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Ubiquitin-Protein Ligase Complexes / antagonists & inhibitors*
Substances
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CDC20 protein, S cerevisiae
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Cdc20 Proteins
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Cell Cycle Proteins
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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CDC20 protein, human
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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Protein Kinases
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BUB1 protein, human
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Bub1 protein, S pombe
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Bub1 spindle checkpoint protein
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Protein Serine-Threonine Kinases