Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis

Trends Cell Biol. 2005 May;15(5):231-3. doi: 10.1016/j.tcb.2005.03.003.

Abstract

To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cdc20 Proteins
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Cell Cycle Proteins / genetics
  • Humans
  • Mitosis / genetics
  • Mitosis / physiology*
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae Proteins / antagonists & inhibitors
  • Saccharomyces cerevisiae Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism
  • Sequence Homology, Amino Acid
  • Ubiquitin-Protein Ligase Complexes / antagonists & inhibitors*

Substances

  • CDC20 protein, S cerevisiae
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • CDC20 protein, human
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Protein Kinases
  • BUB1 protein, human
  • Bub1 protein, S pombe
  • Bub1 spindle checkpoint protein
  • Protein Serine-Threonine Kinases