Abstract
A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / chemical synthesis
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Deoxycytidine / pharmacology
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Drug Screening Assays, Antitumor
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Gemcitabine
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Humans
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Lipids / chemical synthesis*
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Lipids / pharmacology*
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Mice
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Mice, SCID
Substances
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Antineoplastic Agents
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Lipids
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Deoxycytidine
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Gemcitabine