Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies

Leukemia. 2005 Jul;19(7):1267-9. doi: 10.1038/sj.leu.2403775.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation*
  • Dasatinib
  • Models, Molecular
  • Protein Binding / drug effects
  • Protein Conformation
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / chemistry*
  • Proto-Oncogene Proteins c-abl / antagonists & inhibitors
  • Proto-Oncogene Proteins c-abl / chemistry*
  • Pyrimidines / chemistry*
  • Pyrimidines / pharmacology
  • Structure-Activity Relationship
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology

Substances

  • Protein Kinase Inhibitors
  • Pyrimidines
  • Thiazoles
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-abl
  • Dasatinib