The aim of our study was to evaluate the influence of adrenal androgen-DHEAS on lipid metabolism. Observational cross-sectional study was carried out in 57 women aged up to 30 years. Clinical, ultrasound, hormonal investigations were performed. Markers of lipid metabolism-total cholesterol (TC), triglycerides (TG), high density lipoproteides (HDL), low density lipoproteides (LDL), very low density lipoproteides (VLDL) and atherogenic index (IAT) were detected. According to our results DHEAS decreases the production of TC, TG, LDL, VLDL and blocks atherogenic effect of the testosterone. It may be concluded that adrenal androgen-DHEAS has antiatherogenic effect. It has a long-lasting action on the lipid exchange and induces decrease of the level of atherogenic lipids.