Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients

Salomon Ohana; Veronique Leflon; Esthel Ronco; Martin Rottman; Didier Guillemot; Sylvie Lortat-Jacob; Pierre Denys; Georges Loubert; Marie-Helène Nicolas-Chanoine; Jean-Louis Gaillard; Christine Lawrence

doi:10.1128/AAC.49.5.2095-2097.2005

Spread of a Klebsiella pneumoniae strain producing a plasmid-mediated ACC-1 AmpC beta-lactamase in a teaching hospital admitting disabled patients

Antimicrob Agents Chemother. 2005 May;49(5):2095-7. doi: 10.1128/AAC.49.5.2095-2097.2005.

Authors

Salomon Ohana¹, Veronique Leflon, Esthel Ronco, Martin Rottman, Didier Guillemot, Sylvie Lortat-Jacob, Pierre Denys, Georges Loubert, Marie-Helène Nicolas-Chanoine, Jean-Louis Gaillard, Christine Lawrence

Affiliation

¹ Laboratoire de microbiologie, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France.

Abstract

We describe a large outbreak involving a Klebsiella pneumoniae strain producing a plasmid-encoded ACC-1 type AmpC beta-lactamase in a hospital caring for patients with motor impairment. The epidemic strain was isolated from 57 patients in six wards between September 1999 and May 2003 and caused clinical infections in 19 patients.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / genetics*
Cross Infection / epidemiology*
Cross Infection / microbiology*
DNA Primers
Disabled Persons
Drug Resistance, Bacterial
Female
France / epidemiology
Hospitals, Teaching
Humans
Klebsiella Infections / epidemiology*
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / genetics
Male
Microbial Sensitivity Tests
Middle Aged
Plasmids / genetics*
Reverse Transcriptase Polymerase Chain Reaction
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Bacterial Proteins
DNA Primers
AmpC beta-lactamases
beta-Lactamases