Detection of RNA nucleobase metalation by NMR spectroscopy

Chem Commun (Camb). 2005 Apr 28:(16):2069-79. doi: 10.1039/b415137m. Epub 2005 Feb 16.

Abstract

Nucleic acids possess several metal cation recognition sites, including phosphates, nucleobases and possibly riboses. This article focuses on the detection of nucleobase-metal interactions by NMR spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Pairing
  • Binding Sites
  • Binding, Competitive
  • Metals / chemistry*
  • Models, Molecular
  • Nuclear Magnetic Resonance, Biomolecular / methods*
  • Nucleic Acid Conformation
  • RNA / chemistry*
  • RNA, Catalytic / chemistry

Substances

  • Metals
  • RNA, Catalytic
  • hammerhead ribozyme
  • RNA