Abstract
Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Biofilms / growth & development*
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Gene Expression Regulation, Bacterial*
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Humans
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Microscopy, Electron, Scanning
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Molecular Sequence Data
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Streptococcus mutans / genetics
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Streptococcus mutans / growth & development*
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Streptococcus mutans / metabolism
Substances
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Bacterial Proteins
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Smu0630 protein, Streptococcus mutans