Palladium-catalyzed intermolecular three-component coupling of aryl iodides, alkynes, and alkenes to produce 1,3-butadiene derivatives

Kana Shibata; Tetsuya Satoh; Masahiro Miura

doi:10.1021/ol0503743

Palladium-catalyzed intermolecular three-component coupling of aryl iodides, alkynes, and alkenes to produce 1,3-butadiene derivatives

Org Lett. 2005 Apr 28;7(9):1781-3. doi: 10.1021/ol0503743.

Authors

Kana Shibata¹, Tetsuya Satoh, Masahiro Miura

Affiliation

¹ Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

PMID: 15844905
DOI: 10.1021/ol0503743

Abstract

[reaction: see text] The sequential three-component coupling of aryl iodides, diarylacetylenes, and monosubstituted alkenes effectively proceeds in the presence of Pd(OAc)(2), LiCl, and NaHCO(3) as catalyst, promoter, and base, respectively, in DMF-H(2)O to produce the corresponding 1,3-butadiene derivatives.