A novel and efficient method for cleavage of phenacylesters by magnesium reduction with acetic acid

Stella Kokinaki; Leondios Leondiadis; Nikolas Ferderigos

doi:10.1021/ol050209n

A novel and efficient method for cleavage of phenacylesters by magnesium reduction with acetic acid

Org Lett. 2005 Apr 28;7(9):1723-4. doi: 10.1021/ol050209n.

Authors

Stella Kokinaki¹, Leondios Leondiadis, Nikolas Ferderigos

Affiliation

¹ Laboratory of Organic Chemistry, Chemistry Department, University of Athens, 15771 Greece.

PMID: 15844890
DOI: 10.1021/ol050209n

Abstract

[reaction: see text] In the present study, we use magnesium turnings as a new deprotection reagent for the phenacyl group during orthogonal organic synthesis in the presence of other esters and sensitive protecting groups. By applying the new magnesium turnings/acetic acid deprotection method, phenacyl group can be more easily combined with other protecting groups that are not compatible with the zinc/acetic acid method.