Objective: To study the changes of plasma Nt-proBNP levels obtained at multi-time-points during heart failure patients underwent treatment and the relationship between the concentrations to the patients' clinical improvements.
Methods: Forty heart failure patients and 41 normal control patients were chosen. The heart function and clinical characteristics were evaluated. The plasma level of Nt-proBNP was measured with ELISA method.
Results: The plasma Nt-proBNP levels were higher in heart failure group comparing to the control group significantly and gradually fell down in the progression of treatment, along with the improvement of clinical characteristics. The plasma Nt-proBNP levels at the admission were negatively correlated to the therapeutic reaction. The Nt-proBNP levels of patients died or with ventricular fibrillation during admission were higher than others and were apt to elevate during treatment but without statistic significant.
Conclusion: The plasma Nt-proBNP level can be the biochemical indicator of monitoring to heart failure patients in long term treatment.