The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine

PLoS Med. 2005 Apr;2(4):e110. doi: 10.1371/journal.pmed.0020110. Epub 2005 Apr 26.

Abstract

Filarial nematodes contain endosymbiotic bacteria of the genus Wolbachia. As described in the April 2005 issue of PLoS Biology, Foster et al. have sequenced the genome of the Wolbachia that lives in the nematode Brugia malayi. What are the clinical implications?

MeSH terms

  • Animals
  • Brugia malayi / microbiology*
  • Brugia malayi / pathogenicity*
  • Filariasis / drug therapy*
  • Filariasis / prevention & control
  • Filaricides / pharmacology*
  • Genome
  • Humans
  • Phenotype
  • Sequence Analysis, DNA
  • Wolbachia / genetics*

Substances

  • Filaricides