Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines

Dorothée Razafimahefa; Dimby Andrianina Ralambomanana; Lies Hammouche; Lydie Pélinski; Sylvia Lauvagie; Christiane Bebear; Jacques Brocard; Jeanne Maugein

doi:10.1016/j.bmcl.2005.03.004

Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines

Bioorg Med Chem Lett. 2005 May 2;15(9):2301-3. doi: 10.1016/j.bmcl.2005.03.004.

Authors

Dorothée Razafimahefa¹, Dimby Andrianina Ralambomanana, Lies Hammouche, Lydie Pélinski, Sylvia Lauvagie, Christiane Bebear, Jacques Brocard, Jeanne Maugein

Affiliation

¹ Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences d'Antananarivo, B.P. 906, 101 Antananarivo, Madagascar.

PMID: 15837313
DOI: 10.1016/j.bmcl.2005.03.004

Abstract

A new series of ferrocenyl diamino alcohols and diamines were synthesized and their inhibitory potencies were probed with Mycobacterium tuberculosis. Interestingly, ferrocenyl diamines 6a and b display significant activities against M. tuberculosis H37Rv.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / pharmacology
Diamines / chemical synthesis
Diamines / pharmacology
Ethambutol / analogs & derivatives*
Ethambutol / chemical synthesis
Ethambutol / pharmacology
Ferrous Compounds / chemical synthesis*
Ferrous Compounds / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Structure-Activity Relationship

Substances

Antitubercular Agents
Diamines
Ferrous Compounds
Ethambutol