Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2005 Feb;58(2):95-102. doi: 10.1038/ja.2005.12.

Abstract

A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracyclines / isolation & purification*
  • Anthracyclines / pharmacology*
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology*
  • Bacteria / drug effects
  • Carbohydrate Sequence
  • Cell Line, Tumor
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Humans
  • Microbial Sensitivity Tests
  • Micromonospora / chemistry*
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Romania
  • Soil Microbiology
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology

Substances

  • Anthracyclines
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Xanthones
  • retymicin
  • saquayamycin Z
  • galtamycin