Abstract
A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthracyclines / isolation & purification*
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Anthracyclines / pharmacology*
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology*
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Bacteria / drug effects
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Carbohydrate Sequence
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Fermentation
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Humans
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Microbial Sensitivity Tests
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Micromonospora / chemistry*
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Microscopy, Electron, Scanning
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Molecular Sequence Data
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Romania
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Soil Microbiology
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Xanthones / isolation & purification*
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Xanthones / pharmacology
Substances
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Anthracyclines
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Xanthones
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retymicin
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saquayamycin Z
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galtamycin