Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

Cancer Res. 2005 Apr 15;65(8):2990-2. doi: 10.1158/0008-5472.CAN-05-0439.

Abstract

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Genes, Tumor Suppressor
  • Hedgehog Proteins
  • Humans
  • Male
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Oncogene Proteins / biosynthesis
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism*
  • Patched Receptors
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • Receptors, Cell Surface / biosynthesis
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Trans-Activators / biosynthesis
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Zinc Finger Protein GLI1

Substances

  • Hedgehog Proteins
  • Membrane Proteins
  • Oncogene Proteins
  • Patched Receptors
  • Receptors, Cell Surface
  • Trans-Activators
  • Transcription Factors
  • Zinc Finger Protein GLI1