Abstract
The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Genes, Tumor Suppressor
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Hedgehog Proteins
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Humans
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Male
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Membrane Proteins / biosynthesis
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Oncogene Proteins / biosynthesis
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Patched Receptors
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / metabolism*
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Receptors, Cell Surface / biosynthesis
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism*
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Signal Transduction
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Trans-Activators / biosynthesis
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Trans-Activators / genetics
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Trans-Activators / metabolism*
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Transcription Factors / biosynthesis
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Zinc Finger Protein GLI1
Substances
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Hedgehog Proteins
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Membrane Proteins
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Oncogene Proteins
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Patched Receptors
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Receptors, Cell Surface
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Trans-Activators
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Transcription Factors
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Zinc Finger Protein GLI1