Cytotoxic constituents of the octocoral Dendronephthya gigantea

Arch Pharm Res. 2005 Mar;28(3):290-3. doi: 10.1007/BF02977794.

Abstract

A known monoalkyl glycerol ether, (+/-)-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes / chemistry
  • Alkadienes / isolation & purification*
  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Ceramides / chemistry
  • Ceramides / isolation & purification*
  • Drug Screening Assays, Antitumor
  • Glyceryl Ethers / chemistry
  • Glyceryl Ethers / isolation & purification*
  • Glyceryl Ethers / pharmacology
  • Humans

Substances

  • (2S,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1,3-diol
  • 1-nonadecyloxy-2,3-propanediol
  • Alkadienes
  • Antineoplastic Agents
  • Ceramides
  • Glyceryl Ethers