Liquid crystal displays (LCD) are rapidly replacing cathode ray tube displays (CRT) for medical imaging. LCD technology has improved significantly in the last few years and has important advantages over CRT. However, there are still some aspects of LCD that raise questions as to the usefulness of liquid crystal displays for very subtle clinical diagnosis such as mammography. One drawback of modern LCD displays is the existence of spatial noise expressed as measurable stationary differences in the behavior of individual pixels. This type of noise can be described as a random stationary image superposed on top of the medical image being displayed. It is obvious that this noise image can make subtle structures invisible or add nonexistent patterns to the medical image. In the first case, subtle abnormalities in the medical image could remain undetected, whereas in the second case, it could result into a false positive. This paper describes a method to characterize the spatial noise present in high-resolution medical displays and a technique to solve the problem. A medical display with built-in compensation for the spatial noise at pixel level was developed and improved image quality is demonstrated.