Insulin growth factors may be implicated in human sperm capacitation

Silvia Sánchez-Luengo; Pedro J Fernández; Alberto Romeu

doi:10.1016/j.fertnstert.2004.12.003

Insulin growth factors may be implicated in human sperm capacitation

Fertil Steril. 2005 Apr;83(4):1064-6. doi: 10.1016/j.fertnstert.2004.12.003.

Authors

Silvia Sánchez-Luengo¹, Pedro J Fernández, Alberto Romeu

Affiliation

¹ Human Reproduction Department, Hospital la Fe, Avda Campanar 21, 46009 Valencia, Spain. sslvalencia@lycos.es

PMID: 15820831
DOI: 10.1016/j.fertnstert.2004.12.003

Abstract

This study was designed to determine whether or not insulin-like growth factor (IGF)-1 and its receptor are present in the human male genital tract. The IGF-1 receptor was found in seminal plasma from fertile and infertile men, but no IGF-1 receptor was observed in sperm from patients with a history of more failed fertilization. The presence of the IGF-1 receptor in the plasma membrane of human sperm is proposed as a future tool for male sterility assessment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fertility / physiology
Fluorescent Antibody Technique
Humans
Infertility, Male / metabolism*
Insulin-Like Growth Factor I / metabolism*
Male
Receptor, IGF Type 1 / metabolism*
Semen / metabolism
Sperm Capacitation / physiology*

Substances

Insulin-Like Growth Factor I
Receptor, IGF Type 1