In a variety of species, strain differences in aggressive behaviors strongly indicate genetic influences. In people, as suggested, for example, by the work of Kagan, Rothbart, Cloninger, and their collaborators, long-lasting differences in temperament argue for genetic as well as environmental effects. After well-controlled experimentation in mice, we have learned five lessons about gene/behavior causal relations bearing on sociosexual and aggressive behaviors. The effect of a given gene on a given behavior depends upon: (1) exactly when and where that gene is expressed in the brain; (2) the gender of the animal in which it is expressed; (3) the age of the animal; (4) the nature of the opponent; and (5) the form of aggression (e.g., testosterone-facilitated aggression vs. maternal aggression). Moreover, in female mice, better social recognition is correlated with lower levels of aggression. We have gathered evidence for a four-gene micronet involving estrogen receptors alpha and beta, oxytocin, and the oxytocin receptor as expressed in the hypothalamus and amygdala. Normal performance of this micronet is required for social recognition and thus for control over aggression. Underlying certain genetic influences on sociosexual behaviors and aggression may be alterations in generalized brain arousal.