Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]

Chem Res Toxicol. 1992 Jan-Feb;5(1):2-5. doi: 10.1021/tx00025a001.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaldehyde / analogs & derivatives*
  • Acetaldehyde / chemistry
  • Animals
  • Cytochrome P-450 Enzyme System / metabolism
  • DNA / chemistry*
  • Ethylene Oxide / analogs & derivatives*
  • Ethylene Oxide / chemistry
  • Horses
  • In Vitro Techniques
  • Kinetics
  • Male
  • Microsomes, Liver / enzymology
  • Oxidation-Reduction
  • Rats
  • Rats, Inbred Strains
  • Vinyl Chloride / chemistry*

Substances

  • chloroethylene oxide
  • DNA
  • Cytochrome P-450 Enzyme System
  • chloroacetaldehyde
  • Acetaldehyde
  • Ethylene Oxide
  • Vinyl Chloride