Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus

Z Naturforsch C J Biosci. 2004 Jul-Aug;59(7-8):481-4. doi: 10.1515/znc-2004-7-805.

Abstract

In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Biphenyl Compounds
  • Chalcone / analogs & derivatives*
  • Chalcone / chemistry*
  • Chalcone / isolation & purification
  • Chalcone / pharmacology
  • Chalcones
  • Fagaceae / chemistry*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification
  • Free Radical Scavengers / pharmacology*
  • Glucosides
  • Glutathione Peroxidase / metabolism
  • Hydrazines
  • Lipid Peroxidation / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Picrates
  • Plant Leaves / chemistry*
  • Rats
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Chalcones
  • Free Radical Scavengers
  • Glucosides
  • Hydrazines
  • Picrates
  • Chalcone
  • 1,1-diphenyl-2-picrylhydrazyl
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • dihydrochalcone