Convergent synthesis of a fully lipidated glycosylphosphatidylinositol anchor of Plasmodium falciparum

Xinyu Liu; Yong-Uk Kwon; Peter H Seeberger

doi:10.1021/ja042374o

Convergent synthesis of a fully lipidated glycosylphosphatidylinositol anchor of Plasmodium falciparum

J Am Chem Soc. 2005 Apr 13;127(14):5004-5. doi: 10.1021/ja042374o.

Authors

Xinyu Liu¹, Yong-Uk Kwon, Peter H Seeberger

Affiliation

¹ Laboratory for Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Str. 10, HCI F315, 8093 Zürich, Switzerland.

PMID: 15810819
DOI: 10.1021/ja042374o

Abstract

A highly convergent strategy for the synthesis of fully lipidated GPI anchors of malarial origin is reported. This strategy utilized three orthogonal protecting groups, which can be chemoselectively deprotected and functionalized in the late stage of the synthesis. Rapid access to the target GPIs in a highly efficient manner in sufficient quantities for the biological studies has been achieved.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbohydrate Sequence
Glycosylphosphatidylinositols / chemical synthesis*
Glycosylphosphatidylinositols / chemistry
Molecular Sequence Data
Plasmodium falciparum / metabolism*

Substances

Glycosylphosphatidylinositols