Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02

Yoshinosuke Usuki; Koichi Mitomo; Noriko Adachi; Xu Ping; Ken-Ichi Fujita; Osamu Sakanaka; Katsuharu Iinuma; Hideo Iio; Makoto Taniguchi

doi:10.1016/j.bmcl.2005.02.065

Semi-synthesis and biological evaluation of analogues of UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2011-4. doi: 10.1016/j.bmcl.2005.02.065.

Authors

Yoshinosuke Usuki¹, Koichi Mitomo, Noriko Adachi, Xu Ping, Ken-Ichi Fujita, Osamu Sakanaka, Katsuharu Iinuma, Hideo Iio, Makoto Taniguchi

Affiliation

¹ Department of Material Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. usuki@sci.osaka-cu.ac.jp <usuki@sci.osaka-cu.ac.jp>

PMID: 15808458
DOI: 10.1016/j.bmcl.2005.02.065

Abstract

Several analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were semi-synthesized for structure-activity studies. In vitro antifungal activities of these compounds against Saccharomyces cerevisiae IFO 0203 were evaluated by the conventional paper disk method. Several derivatives exhibited growth inhibitory activity similar to UK-2A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology
Drug Evaluation, Preclinical / methods
Lactones / chemical synthesis*
Lactones / pharmacology
Pyridines / chemical synthesis*
Pyridines / pharmacology
Saccharomyces cerevisiae / drug effects
Saccharomyces cerevisiae / growth & development
Streptomyces / chemistry*

Substances

Antifungal Agents
Lactones
Pyridines
UK 2A