A child with dermatomyositis and a suspicious lymphadenopathy

J Rheumatol. 2005 Apr;32(4):744-6.

Abstract

Dermatomyositis (DM) in adults is frequently associated with cancer. In contrast, juvenile DM (JDM) is predominantly idiopathic and rarely reported with occult neoplasm. We describe a patient who presented with DM that was found to be a paraneoplastic manifestation of nasopharyngeal carcinoma. Although rare, paraneoplastic JDM must be suspected in the presence of unusual features such as elevated inflammatory markers or lymphadenopathy. Accurate clinical assessment including appropriate biopsies is needed before starting glucocorticoid therapy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Carcinoma / complications*
  • Carcinoma / pathology
  • Carcinoma / therapy
  • Combined Modality Therapy
  • Dermatomyositis / complications*
  • Dermatomyositis / pathology
  • Disease-Free Survival
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / pathology
  • Epstein-Barr Virus Infections / therapy
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • In Situ Hybridization
  • Lymphatic Diseases / etiology*
  • Lymphatic Diseases / pathology
  • Male
  • Nasopharyngeal Neoplasms / complications*
  • Nasopharyngeal Neoplasms / pathology
  • Nasopharyngeal Neoplasms / therapy
  • Paraneoplastic Syndromes*
  • RNA, Viral / analysis
  • RNA, Viral / genetics

Substances

  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral