Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells

Trends Cardiovasc Med. 2005 Jan;15(1):9-17. doi: 10.1016/j.tcm.2004.10.004.

Abstract

The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / physiopathology
  • Gene Expression Regulation*
  • Humans
  • Inflammation / genetics*
  • Inflammation / physiopathology
  • Neutrophils / metabolism*
  • Protein Biosynthesis / genetics*
  • RNA, Messenger / genetics*
  • Signal Transduction*

Substances

  • RNA, Messenger