Abstract
We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Chagas Cardiomyopathy / prevention & control*
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Chagas Disease / drug therapy*
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Chagas Disease / parasitology
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Disease Models, Animal
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Ergosterol / antagonists & inhibitors*
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Ergosterol / biosynthesis
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Male
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Mice
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Nitroimidazoles / therapeutic use*
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Triazoles / therapeutic use*
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Trypanocidal Agents / therapeutic use*
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Trypanosoma cruzi / drug effects
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Trypanosoma cruzi / pathogenicity
Substances
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Nitroimidazoles
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Triazoles
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Trypanocidal Agents
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TAK 187
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benzonidazole
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Ergosterol