Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease

Antimicrob Agents Chemother. 2005 Apr;49(4):1556-60. doi: 10.1128/AAC.49.4.1556-1560.2005.

Abstract

We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Chagas Cardiomyopathy / prevention & control*
  • Chagas Disease / drug therapy*
  • Chagas Disease / parasitology
  • Disease Models, Animal
  • Ergosterol / antagonists & inhibitors*
  • Ergosterol / biosynthesis
  • Male
  • Mice
  • Nitroimidazoles / therapeutic use*
  • Triazoles / therapeutic use*
  • Trypanocidal Agents / therapeutic use*
  • Trypanosoma cruzi / drug effects
  • Trypanosoma cruzi / pathogenicity

Substances

  • Nitroimidazoles
  • Triazoles
  • Trypanocidal Agents
  • TAK 187
  • benzonidazole
  • Ergosterol