Randomized controlled trial comparing the controlled rehabilitation with early ambulation and diet pathway versus the controlled rehabilitation with early ambulation and diet with preemptive epidural anesthesia/analgesia after laparotomy and intestinal resection

Am J Surg. 2005 Mar;189(3):268-72. doi: 10.1016/j.amjsurg.2004.11.012.

Abstract

Background: Multimodal postoperative care regimens accelerate recovery after abdominal surgery. The benefit of thoracic epidural (TE) analgesia over patient-controlled analgesia (PCA) remains unproven when used with a fast-track postoperative care plan.

Methods: Fifty-six patients undergoing major intestinal resection, and on a fast-track postoperative care plan, were randomized to preemptive TE or PCA. Patients were evaluated at standard time points for pain score, quality of life (Short Form-36), and complications. Oral analgesia was substituted for TE and PCA on the second postoperative day. Discharge criteria were identical for both groups.

Results: Six patients (20.6%) had a failed epidural. There was no difference in length of stay (5.8 versus 6.2 days, TE versus PCA, P = .55), total length of stay (including readmissions), pain scores, quality of life, complications, or hospital costs at any time point.

Conclusion: TE offers no advantage over PCA for patients undergoing major intestinal resections who are on a fast-track postoperative care plan using PCA.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analgesia, Patient-Controlled*
  • Analgesics, Opioid / administration & dosage
  • Anesthesia, Epidural*
  • Anesthetics, Local / administration & dosage
  • Bupivacaine / administration & dosage
  • Colectomy / adverse effects
  • Colectomy / rehabilitation*
  • Early Ambulation
  • Female
  • Humans
  • Intestines / physiopathology
  • Length of Stay
  • Male
  • Middle Aged
  • Morphine / administration & dosage
  • Pain Measurement
  • Pain, Postoperative / etiology
  • Pain, Postoperative / prevention & control*
  • Pain, Postoperative / rehabilitation
  • Premedication*
  • Quality of Life
  • Recovery of Function / physiology

Substances

  • Analgesics, Opioid
  • Anesthetics, Local
  • Morphine
  • Bupivacaine