Abstract
The serum concentration of the angiotensin converting enzyme (ACE) depends on the individual genotype. Thus, ACE levels might be higher (DD-genotype), intermediate (ID) or low (II). Pre-therapeutic determination of the genotype might therefore optimize therapy with ACE-inhibitors or angiotensin II blockers. However, although numerous interventional studies have been performed they are hampered by a low number of included patients and have often yielded differing results. Thus, in order to overcome current controversies larger multicenter studies are warranted before recommending a general testing for genotype prior to initiation of therapy which interferes with the rennin-angiotensin-aldosterone system.
MeSH terms
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Angiotensin II Type 1 Receptor Blockers / administration & dosage
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Angiotensin II Type 1 Receptor Blockers / therapeutic use
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / therapeutic use
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Atenolol / administration & dosage
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Atenolol / therapeutic use
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Biphenyl Compounds / administration & dosage
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Biphenyl Compounds / therapeutic use
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Diabetic Nephropathies / drug therapy
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Genetic Variation*
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Genotype
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Humans
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Hypertension / drug therapy*
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Irbesartan
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Kidney Diseases / drug therapy*
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Myocardial Infarction / genetics*
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Myocardial Infarction / mortality
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Peptidyl-Dipeptidase A / genetics*
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Polymorphism, Genetic*
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Prognosis
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Tetrazoles / administration & dosage
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Tetrazoles / therapeutic use
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Time Factors
Substances
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Angiotensin II Type 1 Receptor Blockers
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Biphenyl Compounds
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Tetrazoles
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Atenolol
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Peptidyl-Dipeptidase A
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Irbesartan