Diastereoselective synthesis of polysubstituted pyrrolidinone as a key intermediate for the anticancer agents by palladium(II)-catalyzed carboxylation

Arch Pharm Res. 2005 Feb;28(2):151-8. doi: 10.1007/BF02977706.

Abstract

Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition (K2CO3), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Catalysis
  • Chromatography, Gel
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Palladium / chemistry
  • Pyrrolidinones / chemical synthesis*
  • Pyrrolidinones / pharmacology*
  • Solvents
  • Stereoisomerism

Substances

  • Alkenes
  • Antineoplastic Agents
  • Indicators and Reagents
  • Pyrrolidinones
  • Solvents
  • Palladium