A series of N-fatty acyl tryptamines, including a mixture of N-nonadecanoyltryptamine (1), N-behenoyltryptamine (2), N-lignoceroyltryptamine (3), N-cerotoyltryptamine (4), and N-octacosanoyl tryptamine (5), and a mixture of N-tricosanoyl-4,5-dihydroxytryptamine (6), N-lignoceroyl-4,5-dihydroxytryptamine (7), N-pentacosanoyl-4,5-dihydroxytryptamine (8), and N-heptacosanoyl-4,5-dihydroxytryptamine (9), along with two alkaloids, atemoine (10) and cleistopholine, were isolated from the EtOAc extract of seeds of Annona atemoya. The structures of the new compounds, 1 and 5-10, were determined on the basis of spectral evidence.