Abstract
Two new hemiterpene glucosides named pubescenosides A and B were isolated from the root of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic and chemical evidence as 2-(trans-caffeoyloxy)methyl-3-hydroxy-1-butene-4-O-beta-D-glucopyranoside and 2-hydroxymethyl-3-caffeoyloxy-1-butene-4-O-beta-D-glucopyranoside, respectively. Pharmacological investigation on pubescenosides A and B indicated that both possess potent anti-platelet aggregation activities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Glucosides / chemistry
-
Glucosides / isolation & purification*
-
Glucosides / pharmacology
-
Hemiterpenes / chemistry
-
Hemiterpenes / isolation & purification*
-
Hemiterpenes / pharmacology
-
Ilex / chemistry*
-
Molecular Structure
-
Plants, Medicinal / chemistry*
-
Platelet Aggregation / drug effects*
-
Platelet Function Tests
-
Rats
Substances
-
Drugs, Chinese Herbal
-
Glucosides
-
Hemiterpenes
-
pubescenoside A
-
pubescenoside B