Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens

J Nat Prod. 2005 Mar;68(3):397-9. doi: 10.1021/np049735y.

Abstract

Two new hemiterpene glucosides named pubescenosides A and B were isolated from the root of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic and chemical evidence as 2-(trans-caffeoyloxy)methyl-3-hydroxy-1-butene-4-O-beta-D-glucopyranoside and 2-hydroxymethyl-3-caffeoyloxy-1-butene-4-O-beta-D-glucopyranoside, respectively. Pharmacological investigation on pubescenosides A and B indicated that both possess potent anti-platelet aggregation activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Hemiterpenes / chemistry
  • Hemiterpenes / isolation & purification*
  • Hemiterpenes / pharmacology
  • Ilex / chemistry*
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Platelet Aggregation / drug effects*
  • Platelet Function Tests
  • Rats

Substances

  • Drugs, Chinese Herbal
  • Glucosides
  • Hemiterpenes
  • pubescenoside A
  • pubescenoside B