Abstract
In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibiotics, Antineoplastic / chemistry
-
Antibiotics, Antineoplastic / isolation & purification*
-
Antibiotics, Antineoplastic / pharmacology
-
Drug Screening Assays, Antitumor
-
Humans
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Polyenes / chemistry
-
Polyenes / isolation & purification*
-
Polyenes / pharmacology
-
Polyunsaturated Alkamides
-
Streptomyces / chemistry*
-
Tumor Cells, Cultured
Substances
-
Antibiotics, Antineoplastic
-
Polyenes
-
Polyunsaturated Alkamides
-
chinikomycin A
-
chinikomycin B
-
manumycin