3,4,5,3',5'-Pentabromo-2-(2'-hydroxybenzoyl)pyrrole: a potential lead compound as anti-Gram-positive and anti-biofilm agent

Int J Antimicrob Agents. 2005 Apr;25(4):338-40. doi: 10.1016/j.ijantimicag.2004.11.014.

Abstract

The activity against Gram-positive bacteria of 3,4,5,3',5'-pentabromo-2-(2'-hydroxybenzoyl)pyrrole I, a synthetic anti-bacterial compound related to pyrrolomycins, was tested in vitro using seven reference bacterial strains and Staphylococcus epidermidis and Staphylococcus aureus preformed biofilms. Compound I was active against all strains tested, with minimum inhibitory concentration (MIC) values ranging from 0.002 to 0.097 mg/l and minimum bactericidal concentrations (MBCs) from 0.37 to 12.5 mg/l. Compound I was also active at low concentrations against preformed S. epidermidis and S. aureus biofilms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects*
  • Drug Resistance, Bacterial
  • Gentian Violet / metabolism
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / growth & development
  • Humans
  • Hydrocarbons, Brominated / chemical synthesis
  • Hydrocarbons, Brominated / chemistry
  • Hydrocarbons, Brominated / pharmacology*
  • Microbial Sensitivity Tests
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*
  • Tetrazolium Salts / metabolism
  • Thiazoles / metabolism

Substances

  • 3,4,5,3',5'-pentabromo-2-(2'-hydroxybenzoyl)pyrrole
  • Anti-Bacterial Agents
  • Hydrocarbons, Brominated
  • Pyrroles
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue
  • Gentian Violet