Abstract
The activity against Gram-positive bacteria of 3,4,5,3',5'-pentabromo-2-(2'-hydroxybenzoyl)pyrrole I, a synthetic anti-bacterial compound related to pyrrolomycins, was tested in vitro using seven reference bacterial strains and Staphylococcus epidermidis and Staphylococcus aureus preformed biofilms. Compound I was active against all strains tested, with minimum inhibitory concentration (MIC) values ranging from 0.002 to 0.097 mg/l and minimum bactericidal concentrations (MBCs) from 0.37 to 12.5 mg/l. Compound I was also active at low concentrations against preformed S. epidermidis and S. aureus biofilms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Biofilms / drug effects*
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Drug Resistance, Bacterial
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Gentian Violet / metabolism
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / growth & development
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Humans
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Hydrocarbons, Brominated / chemical synthesis
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Hydrocarbons, Brominated / chemistry
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Hydrocarbons, Brominated / pharmacology*
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Microbial Sensitivity Tests
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Tetrazolium Salts / metabolism
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Thiazoles / metabolism
Substances
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3,4,5,3',5'-pentabromo-2-(2'-hydroxybenzoyl)pyrrole
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Anti-Bacterial Agents
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Hydrocarbons, Brominated
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Pyrroles
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Tetrazolium Salts
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Thiazoles
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thiazolyl blue
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Gentian Violet