Anti-GBM and anti-MPO antibodies coexist in a case of pulmonary renal syndrome

Pediatr Nephrol. 2005 Jun;20(6):807-10. doi: 10.1007/s00467-004-1762-z. Epub 2005 Mar 22.

Abstract

The case of a 12-year-old boy with pulmonary renal syndrome is described. Antimyeloperoxidase (anti-MPO) and antiglomerular basement membrane (anti-GBM) antibodies were positive. The clinical course and immunosuppressive therapy are discussed. Pulmonary renal syndrome is a rare event in childhood and coexistence of the two types of antibodies is exceptional.

Publication types

  • Case Reports

MeSH terms

  • Antibodies / blood*
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Autoantibodies / blood*
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / therapy
  • Child
  • Glomerulonephritis / immunology*
  • Glomerulonephritis / metabolism
  • Glomerulonephritis / pathology
  • Hemorrhage / immunology*
  • Humans
  • Immunoglobulin G / metabolism
  • Immunosuppression Therapy
  • Lung Diseases / immunology*
  • Male
  • Peroxidase / immunology*
  • Syndrome

Substances

  • Antibodies
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Immunoglobulin G
  • antiglomerular basement membrane antibody
  • Peroxidase