Bone mass acquisition in healthy children

Arch Dis Child. 2005 Apr;90(4):373-8. doi: 10.1136/adc.2004.053553.

Abstract

Although 80% of the variance in bone mass is determined genetically, there are many other factors which influence the accumulation of bone in early life and affect future risks of osteoporosis. This review considers the genetic, fetal, and environmental influences on bone mass acquisition in healthy children, and highlights important areas where paediatricians may have a role by counselling children and their families to adopt a healthy lifestyle which promotes bone health.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Bone Density / genetics
  • Bone Density / physiology*
  • Bone Development / genetics
  • Bone Development / physiology*
  • Calcium / administration & dosage
  • Child
  • Child Nutritional Physiological Phenomena / physiology
  • Collagen Type I / genetics
  • Diet
  • Exercise / physiology
  • Fetal Development / physiology
  • Fractures, Bone / etiology
  • Growth / physiology*
  • Hormones / physiology
  • Humans
  • LDL-Receptor Related Proteins
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Polymorphism, Genetic
  • Receptors, Calcitriol / genetics
  • Receptors, LDL / genetics
  • Vitamin D / administration & dosage

Substances

  • Collagen Type I
  • Hormones
  • LDL-Receptor Related Proteins
  • LRP5 protein, human
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Receptors, Calcitriol
  • Receptors, LDL
  • Vitamin D
  • Calcium