Abstract
Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols
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Humans
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Mice
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Neoplasms / drug therapy*
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Neovascularization, Pathologic / drug therapy*
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents