Local anesthetic agents are administered before many ambulatory cutaneous operations. The injection of the local anesthetic agent is often the only painful aspect of the procedure. There are various factors that determine how painful the anesthetic administration may be. These include the preparation used, the size of the needle and syringe used, injection technique, depth of injection, attitude of the physician, and more. In this article, we present the different techniques we apply to achieve minimal pain during the injection of local anesthetics.