Exercise your amyloid

Stanislav L Karsten; Daniel H Geschwind

doi:10.1016/j.cell.2005.02.027

Exercise your amyloid

Cell. 2005 Mar 11;120(5):572-4. doi: 10.1016/j.cell.2005.02.027.

Authors

Stanislav L Karsten¹, Daniel H Geschwind

Affiliation

¹ Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

PMID: 15766520
DOI: 10.1016/j.cell.2005.02.027

Abstract

The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD.

Publication types

Comment
Review

MeSH terms

Alzheimer Disease / genetics
Alzheimer Disease / metabolism
Alzheimer Disease / prevention & control*
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism*
Animals
Brain / metabolism*
Brain / pathology
Brain / physiopathology
Disease Models, Animal
Environment, Controlled*
Exploratory Behavior / physiology
Gene Expression Regulation / genetics*
Humans
Neprilysin / metabolism
Physical Conditioning, Animal / physiology

Substances

Amyloid beta-Peptides
Neprilysin