Abstract
The application of Penicillium notatum genus for biotransformations of steroids has been investigated. The reactions observed include insertion of an oxygen atom into D-ring of steroids, 15alpha-hydroxylation of 17alpha-methyl testosterone derivatives, ester bond hydrolysis, and degradation of a testosterone derivatives side chain. Microbial production of testolactones, the biologically active compounds, was also achieved using this strain in up to 98% yield.
MeSH terms
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Androstenedione / chemistry
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Cell Culture Techniques / methods
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Chromatography, Thin Layer
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Circular Dichroism
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Esters
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Ethisterone / urine
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Methandrostenolone / chemistry
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Methyltestosterone / chemistry
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Models, Chemical
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Nandrolone / chemistry
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Oxygen / metabolism
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Penicillium / metabolism*
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Progesterone / chemistry
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Spectrophotometry
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Spectrophotometry, Infrared
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Testosterone / analogs & derivatives
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Testosterone / chemistry
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Testosterone / metabolism
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Testosterone Propionate / chemistry
Substances
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Esters
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Testosterone
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Androstenedione
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Progesterone
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boldenone
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Nandrolone
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Methandrostenolone
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Ethisterone
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Oxygen
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Methyltestosterone
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Testosterone Propionate