Whereas currently available local anesthetics may be suitable for intraoperative and in-hospital postoperative use, long-acting analgesia after outpatient procedures will require new techniques and drugs. Catheter delivery systems are rapidly gaining clinical acceptance and allow for great flexibility in dosing. Encapsulated local anesthetics can provide the slow release of drugs. Novel, long-acting local anesthetics are being investigated but are not yet ready for clinical use. In addition to the effects on the sodium channel, other actions of these novel compounds need to be explored, because both beneficial and detrimental effects may be induced with these compounds.