Background: Pemphigus vegetans, a variant of pemphigus vulgaris, most commonly occurs in the flexural area.
Objective: To describe an unusual case of pemphigus vegetans occurring in a skin graft recipient site and to discuss the possible etiology.
Methods: We present a 41-year-old man who developed vegetating plaques from the graft recipient site of his left leg for 8 months.
Results: Based on the histopathologic findings of a skin biopsy, this case was diagnosed as pemphigus vegetans. The patient's condition was successfully treated with systemic corticosteroids and acitretin.
Conclusion: Our case is unique in its presentation of pemphigus vegetans shortly after a split-thickness skin graft. Physicians should be aware of this entity while differentiating cutaneous lesions arising from a skin graft.