Microwave-assisted synthesis of isonitriles: a general simple methodology

Andrea Porcheddu; Giampaolo Giacomelli; Margherita Salaris

doi:10.1021/jo047924f

Microwave-assisted synthesis of isonitriles: a general simple methodology

J Org Chem. 2005 Mar 18;70(6):2361-3. doi: 10.1021/jo047924f.

Authors

Andrea Porcheddu¹, Giampaolo Giacomelli, Margherita Salaris

Affiliation

¹ Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, 07100 Sassari. anpo@uniss.it

PMID: 15760232
DOI: 10.1021/jo047924f

Abstract

[reaction: see text] A facile conversion of formamides to isonitriles under very mild conditions and microwave irradiation is described. This simple and efficient method has been applied for the synthesis of both aliphatic and aromatic isonitriles in high yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Microwaves*
Molecular Structure
Nitriles / chemical synthesis*
Nitriles / chemistry
Nitriles / radiation effects
Oxidation-Reduction

Substances

Nitriles