Objective: To discuss the way of animal model building of hepaticocholedochostomy (HC) and hepaticojejunostomy (HJ) and to compare the short-term effect.
Methods: Twenty-nine dogs were divided randomly into control group (n=5) and the experimental group (stenosis of left hepatic duct, n=24). After 7 weeks of stenosis of left hepatic duct, 24 dogs in the experimental group were divided randomly into HC subgroup (n=12) and HJ subgroup (n=12). The operation time and the blood loss during operation were recorded and the hepatic function was detected.
Results: The diameter of left hepatic duct was significantly expended after 7 week's stenosis. Hepaticocholedochostomy took shorter time and lost less blood than hepaticojejunostomy. The dogs in HC subgroup lost less weight than those in HJ subgroup. In HC and HJ subgroups, the mortality rates were 1/12 and 3/12; the infectious rates of incision were 3/12 and 5/12 respectively. Serum levels of total bilirubin and transaminase increased significantly in the 7th week after stenosis of left hepatic duct compared with before stenosis of left hepatic duct. However, Serum levels of total bilirubin and transaminase restored to normal levels after 1 month of HC or HJ.
Conclusion: It is feasible to establish animal model of bile duct reconstruction on the basis of stricture of bile duct. The dogs undergoing hepaticocholedochostomy have less trauma, better results than the dogs undergoing hepaticojejunostomy. Both hepaticocholedochostomy and hepaticojejunostomy are able to relieve the obstruction of bile duct.