Abstract
Transcriptional activation of HIV-1 gene expression is controlled in part by the interaction of viral and cellular transcription factors with the HIV-1 long terminal repeat (LTR) sequences. LTR variability among different HIV-1 subtypes could affect LTR binding of either cellular or viral elements, influencing the transcription level. This effect, in turn, may have consequences on the biology of the different HIV-1 clades and on disease progression. In some circumstances, a relationship between replication capacity in vitro and changes in binding sequences for transcription factors located at the LTR has been proven.
Publication types
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Comparative Study
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cells, Cultured / virology
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Gene Expression Regulation, Viral*
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Gene Products, tat / physiology
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Genetic Variation
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HIV Long Terminal Repeat / genetics
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HIV Long Terminal Repeat / physiology*
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HIV-1 / classification
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HIV-1 / genetics*
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Humans
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Protein Interaction Mapping
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Receptors, Thyroid Hormone / metabolism
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Structure-Activity Relationship
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T-Lymphocytes / virology
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Transcription Factors / metabolism
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Transcription, Genetic*
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tat Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, tat
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Receptors, Thyroid Hormone
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Transcription Factors
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tat Gene Products, Human Immunodeficiency Virus