Background & objective: Angiogenin (ANG), an efficient angiogenesis factor, is up-regulated in human colorectal carcinoma, pancreatic carcinoma, and other tumors. But the function of ANG in tumor angiogenesis is still unknown. This study was to explore the effect of ANG on angiogenesis of gastric carcinoma.
Methods: The expressions of ANG, CD34, and Ki-67 in 68 specimens of gastric carcinoma were detected by immunohistochemistry. Microvessel density (MVD) was figured out according to the expression of CD34. The proliferation index of carcinoma cells in gastric carcinoma tissue was figured out according to the expression of Ki-67.
Results: Of the 68 specimens of gastric carcinoma, 19 showed strongly positive expression of ANG (group A), 3 showed negative expression of ANG (group B). MVD of group A was significantly higher than that of group B (308.4+/-25.6 vs. 196.0+/-31.3, P<0.01). Proliferation index of group A was significantly higher than that of group B (579.6+/-31.4 vs. 341.3+/-84.0, P<0.01).
Conclusion: Protein level of ANG positively correlates with MVD of gastric carcinoma tissue, and proliferation index of carcinoma cells.