Liver transplantation as definitive treatment for a factor V Leiden mutation

J Pediatr. 2005 Mar;146(3):418-22. doi: 10.1016/j.jpeds.2004.10.036.

Abstract

Liver transplantation (LT) was achieved for factor V Leiden-induced thrombophilia in a neonate with hepatic veno-occlusive disease. Initial LT was performed with a liver segment removed from a child with primary oxalosis. Four months later, a second, definitive LT was performed. The child remains well without recurrent thrombosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Factor V / genetics*
  • Hepatic Veno-Occlusive Disease / genetics
  • Hepatic Veno-Occlusive Disease / surgery*
  • Humans
  • Infant, Newborn
  • Liver Failure / genetics
  • Liver Failure / surgery
  • Liver Transplantation*
  • Male
  • Point Mutation*
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA / methods
  • Thrombophilia / genetics
  • Thrombophilia / surgery*

Substances

  • factor V Leiden
  • Factor V