Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line

Haematologica. 2005 Mar;90(3):403-5.

Abstract

The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation / drug effects*
  • Cell Line, Tumor
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Leukemia, Promyelocytic, Acute / pathology*
  • Protein Isoforms
  • Tretinoin / pharmacology
  • WT1 Proteins / analysis*
  • WT1 Proteins / genetics

Substances

  • Protein Isoforms
  • WT1 Proteins
  • Tretinoin