Abstract
The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Differentiation / drug effects*
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Cell Line, Tumor
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Leukemia, Promyelocytic, Acute / drug therapy
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Leukemia, Promyelocytic, Acute / pathology*
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Protein Isoforms
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Tretinoin / pharmacology
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WT1 Proteins / analysis*
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WT1 Proteins / genetics
Substances
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Protein Isoforms
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WT1 Proteins
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Tretinoin