Screening of some medicinal plants for anti-lipase activity

Niti Sharma; Vinay K Sharma; Sung-Yum Seo

doi:10.1016/j.jep.2004.11.009

Screening of some medicinal plants for anti-lipase activity

J Ethnopharmacol. 2005 Mar 21;97(3):453-6. doi: 10.1016/j.jep.2004.11.009.

Authors

Niti Sharma¹, Vinay K Sharma, Sung-Yum Seo

Affiliation

¹ Applied Biotechnology Laboratory, Department of Biology, College of Natural Science, Kongju National University, Kongju 314-701, Korea.

PMID: 15740880
DOI: 10.1016/j.jep.2004.11.009

Abstract

In order to find new pancreatic lipase (triacylglycerol lipase, EC 3.1.1.3) inhibitors from natural sources, 75 medicinal plants belonging to different families were screened for their anti-lipase activity, using a radioactive method. On evaluating the results, methanolic extracts of three plants namely, Eriochloa villosa (Thunb.) Kunth, Orixa japonica Thunb. and Setaria italica (L.) Palib., exhibited strong in vitro anti-lipase activity (above 80%). These plants will be studied further to elucidate the structure and chemical properties of the active compound responsible for anti-lipase action.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Evaluation, Preclinical / methods*
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Lipase / antagonists & inhibitors*
Lipase / metabolism
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Structures
Plants, Medicinal*
Swine

Substances

Enzyme Inhibitors
Plant Extracts
Lipase